澳门新葡亰平台官网师资

陈高帜

博士,校聘研究员。美国纽约大学生物化学与分子药理学系博士后,温州市“海外精英引进计划”创新长期项目人才。主要从事药物化学及结构生物学相关研究。
姓名 陈高帜 性别
学历 博士研究生 职称 校聘研究员
电子邮件 cgztc@163.com

教育经历


2006.09-2010.06,温州医科大学,获学士学位

2010.09-2013.06,温州医科大学,获硕士学位

2013.09-2016.06,温州医科大学,获博士学位



承担科研项目情况


1.国家自然科学青年基金,81703352,靶向作用于FGFR1膜外端结构域的新型小分子抑制剂及初步分子机制研究,2018年-2021年,主持。



研究方向


1.疾病发生发展过程中的信号调控分子机制研究及相关药物开发。



代表性论著


1.Gaozhi Chen#, Yang Liu#, Regina Goetz, Lili Fu, Seetharaman Jayaraman, Ming-Chang Hu, Orson W. Moe, Guang Liang, Xiaokun Li*, Moosa Mohammadi*. a-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature, 2018, 553(7689): 461-466.

2.Gaozhi Chen, Yali zhang, Xing Liu, Qilu Fang, Zhe Wang, Lili Fu, Zhiguo Liu, Yi Wang, Yunjie Zhao, Xiaokun Li, Guang Liang*. Discovery of a new inhibitor of myeloid differentiation 2 from cinnamamide derivatives with anti-inflammatory activity in sepsis and acute lung injury. Journal of Medicinal Chemistry, 2016, 59(6): 2436–2451.

3.Gaozhi Chen#, Bing Xiao#, Lingfeng Chen#, Bin Bai, Yali Zhang, Zheng Xu, Lili Fu, Zhiguo Liu, Xiaokun Li*, Yunjie Zhao*, Guang Liang*. Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury. European journal of medicinal chemistry, 2017, 139: 726-740.

4.Gaozhi Chen, Zhiguo Liu, Yali Zhang, Xiaoou Shan, Lili Jiang, Yunjie Zhao, Wenfei He, Zhiguo Feng, Shulin Yang, Guang Liang*. Synthesis and anti-inflammatory evaluation of novel benzimidazole and imidazopyridine derivatives. ACS Medicinal Chemistry Letters, 2012, 4(1): 69–74.

5.Gaozhi Chen#, Qiaoyou Weng#, Lili Fu, Zhe Wang, Pengtian Yu, Zhiguo Liu, Xiaokun Li, Huajie Zhang*, Guang Liang*. Synthesis and biological evaluation of novel oxindole-based RTK inhibitors as anti-cancer agents. Bioorganic & Medicinal Chemistry, 2014, 22(24): 6953–6960.

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