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张亚利

副研究员
姓名 张亚利 性别
学历 博士研究生 职称 副研究员
电子邮件 ya-li000@163.com




教育经历


2005.09-2009.07  聊城大学化学化工学院,获学士学位(化学工程与工艺)      

2009.09-2014.12  南京理工大学环境与生物工程学院,获博士学位(化学工程与技术)



承担科研项目情况


1.国家自然科学基金青年项目(81503123,2016/01-2018/12,主持)

2.浙江省自然科学基金(LQ14H310003,2014/01-2016/12,主持)



研究方向


1.天然产物及其类似物的抗炎药理学研究



代表性论著


1.Xiaoou Shan#, Yali Zhang#, Hongjin Chen#, Lili Dong, Beibei Wu, Tingting Xu, Jie Hu, Zhiguo Liu, Wei Wang, Liqin Wu, Zhiguo Feng*, Guang Liang*. Inhibition of epidermal growth factor receptor attenuates LPS-induced inflammation and acute lung injury in rats. Oncotarget, 2017, accepted. (IF=5.008)

2. Zhen Wang#, Yali Zhang#, Bartual Sergio, Jinfeng Luo, Tingting Xu, Wenting Du, Qiuju Xun, Zhengchao Tu, Brekken Rolf, Xiaomei ren, Bullock Alex, Guang Liang*, Xiaoyun Lu*, Ke Ding*. Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Medicinal Chemistry Letters, 2017, accepted. (IF= 3.355)

3. Yali Zhang#, Tingting Xu#, Beibei Wu#, Hongjin Chen, Zheer Pan, Yi Huang, Liqin Mei, Yuanrong Dai, Xing Liu*, Xiaoou Shan*, Guang Liang*. Targeting myeloid differentiation protein 2 (MD-2) by the new chalcone L2H21 protects LPS-induced acute lung injury. Journal of Cellular and Molecular Medicine, 2017, 21(4):746-757. (IF=4.938)

4. Yali Zhang, Jianzhang Wu, Shilong Ying, Gaozhi Chen, Beibei Wu, Tingting Xu, Zhiguo Liu, Xing Liu, Lehao Huang, Xiaoou Shan, Yuanrong Dai, Guang Liang*. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Scientific Reports, 2016, 6:25130. (IF=5.228)

5. Zhiguo Liu#, Longguang Tang#, Heping Zhu#, Tingting Xu, Chenyu Qiu, Suqing Zheng, Yugui Gu, Jianpeng Feng, Yali Zhang*, Guang Liang*. Design, synthesis and structure-activity relationship study of novel indole-2-carboxamide derivatives as anti-inflammatory agents for the treatment of sepsis. Journal of Medicinal Chemistry, 2016, 59(10):4637-50. (IF=5.589)


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